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Partition Coefficient |
| see Octanol/water partition coefficient. |
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Passive Transfer |
| The movement across a membrane by simple diffusion. This is the most common way lipophilic xenobiotics pass through cell membranes. |
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Percutaneous absorption |
| The transfer of a substance from the outer surface of the skin through the corneum and outer layers and into the systemic circulation. |
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Phagocytosis |
| The engulfing of particles by certain cells of the circulatory and lymphatic systems, known as phagocytes. Phagocytosis is a primary cellular defense mechanism against foreign particles or organisms. |
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Pharmacokinetics |
| Quantitation of the time course of chemical absorption, distribution, metabolism, and elimination. |
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Phospholipids |
| Molecules containing phosphates and lipids found in the cell membrane. The phosphate head is hydrophilic, whereas the lipid tail is hydrophobic. |
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Pinocytosis |
| The process whereby a liquid is engulfed and taken into a cell by an inward folding of the cell membrane, which detaches and moves into the cytoplasm. |
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Plasma |
| The non-cellular, fluid portion of whole blood. |
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Plasma membrane |
| The membrane composed of phospholipids, proteins, and cholesterol that forms the outer boundary of a cell and regulates the movement of substances into and out of the cell. Same as "cell membrane." |
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Polar |
| A term used to describe a molecule which is charged or ionized. Polar substances are usually the easiest for the body to excrete. |
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Portal circulation |
| The term applied to the venous circulation draining the tissues of the gastrointestinal tract into the liver. |
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PPM |
| Parts per million - the number of units of a substance in a million units. PPM is a common concentration unit for dilute samples of dissolved substances or airborne substances. |
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Protein |
| A complex nitrogenous substance which constitutes the main building material in cells. |
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